abstract：:Ten patients with non-alcoholic cirrhosis and ten control subjects were studied in basal conditions and after ingestion of a standard mixed test meal. Plasma somatostatin, blood glucose, plasma insulin, C-peptide and glucagon were determined before and 15, 30, 45, 60, 90, 120 and 180 min after the start of the meal. B...

journal_title：Journal of hepatology

authors： Barreca T,Franceschini R,Cataldi A,Rolandi E

更新日期：1991-01-01 00:00:00

abstract：:The etiologic agent responsible for epidemics of enterically-transmitted non-A, non-B hepatitis has been molecularly characterized as the hepatitis E virus (HEV). The cloning of a portion of the Burma strain of HEV (HEV(B); 'Old World' strain) has been described together with the isolation of a contiguous overlapping ...

journal_title：Journal of hepatology

authors： Reyes GR,Huang CC,Yarbough PO,Tam AW

更新日期：1991-01-01 00:00:00

abstract：:The presence of HBV-DNA sequences was evaluated in DNA extracted from serum samples, peripheral blood lymphocytes and liver biopsy specimens of five HBsAg/anti-HBe-positive carriers with chronic HDV infection. DNAs were tested by polymerase chain reaction (PCR) amplification technique using two pairs of oligonucleotid...

journal_title：Journal of hepatology

authors： Raimondo G,Rodinò G,Brancatelli S,Sardo MA,Campo S,Smedile V,Villari D,Pernice M,Longo G,Squadrito G

更新日期：1991-01-01 00:00:00

abstract：:The prolylhydroxylase inhibitor HOE 077 which has proven to be liver-selective in animals was tested in general pharmacological and toxicological studies for unwanted effects and safety. The results of these studies permit clinical development. A single-dose study in healthy volunteers was performed which showed that ...

journal_title：Journal of hepatology

authors： Horn W

更新日期：1991-01-01 00:00:00

abstract：:Hepatic fibrosis represents an important stage in the progression of chronic liver disease to cirrhosis. In the present paper we have investigated whether capsaicin-sensitive neuropeptide-containing sensory neurons may participate in the development of liver fibrosis. The expression of hepatic fibrosis induced by comm...

journal_title：Journal of hepatology

authors： Casini A,Lippe IT,Evangelista S,Geppetti P,Santicioli P,Urso C,Paglierani M,Maggi CA,Surrenti C

更新日期：1990-11-01 00:00:00

abstract：:In this paper, we studied the usefulness of polymerase chain reaction (PCR) in HDV-RNA detection. Using serial dilutions of serum samples of known concentrations of HDV-RNA, PCR was 10,000-times more sensitive than slot-blot hybridization. PCR was used for the detection of HDV-RNA in 33 serum samples negative to HDV-R...

journal_title：Journal of hepatology

authors： Madejón A,Castillo I,Bartolomé J,Melero M,Campillo ML,Porres JC,Moreno A,Carreño V

更新日期：1990-11-01 00:00:00

abstract：:Activities of superoxide dismutase, catalase and glutathione peroxidase were measured in liver biopsy specimens from patients with various liver diseases, including six with chronic persistent hepatitis, nine with chronic active hepatitis, nine with non-alcoholic cirrhosis, eight with alcoholic cirrhosis and eight wit...

journal_title：Journal of hepatology

authors： Togashi H,Shinzawa H,Wakabayashi H,Nakamura T,Yamada N,Takahashi T,Ishikawa M

更新日期：1990-09-01 00:00:00

abstract：:It was discovered that eight patients with complications of non-cirrhotic portal hypertension had received an arsenical preparation for psoriasis as Fowler's solution some years age. Seven of them were admitted for bleeding oesophageal varices. Upon admission, splenomegaly and hypersplenism were present. Liver tests w...

journal_title：Journal of hepatology

authors： Nevens F,Fevery J,Van Steenbergen W,Sciot R,Desmet V,De Groote J

更新日期：1990-07-01 00:00:00

abstract：:Liver transplantation is performed successfully across major HLA differences between donor and recipient. This may be influenced by the organ specific expression of major histocompatibility complex (MHC) molecules which determine the local immune reactivity and rejection response. The tissue expression of MHC molecule...

journal_title：Journal of hepatology

authors： Steinhoff G

更新日期：1990-07-01 00:00:00

abstract：:In this report we describe the case of a 7-year-old boy, suffering from autoimmune-type chronic active hepatitis (AI-CAH) associated with vitiligo, nail dystrophy, alopecia areata and a variant of liver kidney microsomal (LKM) autoantibodies. This patient's antibodies are different from LKM-1 which are directed agains...

journal_title：Journal of hepatology

authors： Sacher M,Blümel P,Thaler H,Manns M

更新日期：1990-05-01 00:00:00

abstract：:Ursodeoxycholate has been advocated for the treatment of cholestatic liver diseases. The coinfusion of tauroursodeoxycholate with taurolithocholate in the perfused rat liver completely prevented the decrease of bile flow and the increase of oxygen uptake found with taurolithocholate only. Bile flow and bile salt secre...

journal_title：Journal of hepatology

authors： Schölmerich J,Baumgartner U,Miyai K,Gerok W

更新日期：1990-05-01 00:00:00

abstract：:To summarize, nowadays it seems clear that in patients with cirrhosis: (a) the pulmonary circulation is usually markedly dilated. (b) This vasodilation is due to a loss of vascular tone and it is characterized by a poor (or even absent) vascular reactivity in front of the hypoxic stimulus. (c) This abnormal behaviour ...

journal_title：Journal of hepatology

authors： Agustí AG,Roca J,Bosch J,Rodriguez-Roisin R

更新日期：1990-03-01 00:00:00

abstract：:The presence of hepatitis B virus DNA (HBV-DNA) in the peripheral blood mononuclear cells (PBMC) of 29 anti-HIV symptomless carriers (eleven HBeAg positive, eleven anti-HBe positive and seven HBsAg negative) and of 40 anti-human immunodeficiency virus (HIV)-negative patients (15 HBeAg positive, 15 anti-HBe positive an...

journal_title：Journal of hepatology

authors： Bartolomé FJ,Moraleda G,Castillo I,Martinez MG,Porres JC,Carreño V

更新日期：1990-03-01 00:00:00

abstract：:The effectiveness of recombinant alpha-interferon was evaluated in chronic non-A, non-B hepatitis of parenteral transmission. Thirty patients were randomly allocated two groups: control group (without treatment) and treatment group (alpha-interferon 5 mega units thrice weekly for 2 months, and then 1.5 mega units unti...

journal_title：Journal of hepatology

authors： Gómez-Rubio M,Porres JC,Castillo I,Quiroga JA,Moreno A,Carreño V

更新日期：1990-01-01 00:00:00

abstract：:The clearance of hepatitis B virus infected cells from the liver is probably dependent on an interplay between the interferon system and the cellular limb of the host immune response. Although the importance of the nucleocapsid proteins as targets for sensitized cytotoxic T cells is established in chronic hepatitis B ...

journal_title：Journal of hepatology

authors： Thomas HC

更新日期：1990-01-01 00:00:00

abstract：:The effect of glucagon on the relation between urea synthesis and blood amino acid concentration was studied in seven healthy volunteers. Alanine was given as prime-continuous infusions and, after 1 hr for equilibration, the urea nitrogen synthesis rate was measured in two periods of about 2 hrs as urinary excretion c...

journal_title：Journal of hepatology

authors： Vilstrup H,Hansen BA,Almdal TP

更新日期：1990-01-01 00:00:00

abstract：:In a multicentre trial, 82 patients known to be hepatitis B e antigen and hepatitis B virus DNA positive for at least 1 year, with elevated serum alanine aminotransferase levels and chronic liver lesions on biopsy, were randomized to receive either recombinant interferon alfa-2a at a dose of 4.5 million units thrice w...

journal_title：Journal of hepatology

authors： Realdi G,Fattovich G,Pastore G,Caredda F,Noventa F,Santantonio T,Moroni M,Criscuolo D,Maladorno D,Rugge M

更新日期：1990-01-01 00:00:00

abstract：:In recent years a new concept of the mechanism of hepatic fatty acid uptake has been described. It was shown that this major class of energy yielding substrates enters hepatocytes by a carrier-mediated uptake system. After the dissociation of the fatty acid-albumin complex at the sinusoidal liver cell plasma membrane,...

journal_title：Journal of hepatology

authors： Stremmel W

更新日期：1989-11-01 00:00:00

abstract：:This study evaluates systemic and splanchnic haemodynamics and the effect of propranolol in 15 patients with presinusoidal portal hypertension (portal vein obstruction, n = 11; schistosomiasis, n = 4). These patients exhibited a hyperkinetic circulatory syndrome characterized by high cardiac index (4.4 +/- 1.61.min-1....

journal_title：Journal of hepatology

authors： Braillon A,Moreau R,Hadengue A,Roulot D,Sayegh R,Lebrec D

更新日期：1989-11-01 00:00:00

abstract：:To study experimentally the protective effect of post-exposure prophylaxis against hepatitis B (HB), a special preparation of hepatitis B immune globulin (HBIG) was injected intravenously (i.v.) into three chimpanzees simultaneously with, or at different time intervals after, intravenous injection of a titred inoculum...

journal_title：Journal of hepatology

authors： Wahl M,Iwarson S,Snoy P,Gerety RJ

更新日期：1989-09-01 00:00:00

abstract：:Recently, we have shown that taurocholate transport is impaired in hepatocytes isolated from CCl4 cirrhotic rats. Na+,K+-ATPase activity depends on the lipid composition of the surrounding membrane. Therefore, we performed this study in order to detect differences in plasma membrane composition and membrane functions ...

journal_title：Journal of hepatology

authors： Krähenbühl S,Meier-Abt PJ,Reichen J

更新日期：1989-07-01 00:00:00

abstract：:Fifty-eight gallbladder stones were treated in vitro, using a Wolf Piezolith 2300 lithotripter, to discover whether complete fragmentation (i.e., no particles greater than 2 mm diameter) could be achieved by lithotripsy alone. In 16 stones this was accomplished with up to 6000 shocks being administered. The degree of ...

journal_title：Journal of hepatology

authors： Bird NC,Frost EA,Kanaris-Sotiriou R,Johnson AG

更新日期：1989-07-01 00:00:00

abstract：:Short- and long-term effects of intraperitoneally transplanted microcarrier attached liver cells (MAL) have been studied in two experimental models of severe liver insufficiency in the rat: subtotal hepatectomy (HX) and acute liver ischemia. Intraperitoneal transplantation of MAL immediately after subtotal hepatectomy...

journal_title：Journal of hepatology

authors： Bosman DK,de Haan JG,Smit J,Jorning GG,Maas MA,Chamuleau RA

更新日期：1989-07-01 00:00:00

abstract：:A quantitative immunohistochemical study of Kupffer cells in liver biopsies from alcoholics was carried out. Two markers were compared, lysozyme and an antimacrophage monoclonal antibody EMB/11. The results showed that there is no significant reduction in Kupffer cell numbers in acute and chronic alcoholic liver disea...

journal_title：Journal of hepatology

authors： Kelly PM,Heryet AR,McGee JO

更新日期：1989-03-01 00:00:00

abstract：:Recently reports have indicated that both cimetidine and ranitidine delay cell proliferation in rats following 70% partial hepatectomy and result in an increased mortality following this procedure. The present study was designed to determine whether three H2 blocking agents (cimetidine, ranitidine, famotidine) and a n...

journal_title：Journal of hepatology

authors： Francavilla A,Panella C,Polimeno L,Di Leo A,Makowka L,Barone M,Amoruso A,Ingrosso M,Starzl TE

更新日期：1989-01-01 00:00:00

abstract：:We report a novel method to assess bile secretory pressure using a Statham pressure transducer. The studies were performed in vivo in male Sprague-Dawley rats under pentobarbital anesthesia. Maximal secretory pressure averaged 21.8 +/- 1.1 (S.D.) cmH2O. The bile accumulated after 10 min of obstruction was 7.7 +/- 2.8 ...

journal_title：Journal of hepatology

authors： Cotting J,Reichen J

更新日期：1989-01-01 00:00:00

abstract：:Guinea pig Kupffer cells were obtained by partial digestion of the liver with pronase and collagenase and purified by centrifugal elutriation. Cells were kept in monolayer culture and their capacity to secrete superoxide anion in response to phagocytosis of zymosan was determined by the cytochrome c method. Compared t...

journal_title：Journal of hepatology

authors： Rieder H,Ramadori G,Meyer zum Büschenfelde KH

更新日期：1988-12-01 00:00:00

abstract：:The aim of the present investigation was to study the number and acinar distribution of apoptotic bodies in normal liver as an approach to a better understanding of cell kinetics in the hepatic parenchyma. The material included 20 normal human needle liver biopsies and 20 normal male Sprague-Dawley rats. For each live...

journal_title：Journal of hepatology

authors： Benedetti A,Jézéquel AM,Orlandi F

更新日期：1988-12-01 00:00:00

abstract：:Fulminant hepatic failure has a high mortality rate despite intensive medical treatment. Urgent hepatic transplantation was considered over a 3 year period in 26 (36%) of 73 patients with the worst prognostic features of fulminant hepatic failure. The criteria for patient selection were based on the duration of advanc...

journal_title：Journal of hepatology

authors： Vickers C,Neuberger J,Buckels J,McMaster P,Elias E

更新日期：1988-10-01 00:00:00

abstract：:A case of HIV superinfection observed in an HBsAg/HBeAg-positive male homosexual with chronic persistent hepatitis is described. Soon after the appearance of clinical and serological features of acute HIV infection, a rapid fall to a normal value of ALT was noted with simultaneous recrudescence of HBV replication last...

journal_title：Journal of hepatology

authors： Pastore G,Santantonio T,Monno L,Milella M,Luchena N,Angarano G

更新日期：1988-10-01 00:00:00

abstract：:It has been suggested that the cellular immune response to HBV antigens is responsible for hepatocellular injury in acute and chronic hepatitis B. However, definitive immunological studies have so far been hampered by the lack of appropriate model systems to study HBV antigen-specific T cells. The availability of high...

journal_title：Journal of hepatology

authors： Ferrari C,Penna A,DegliAntoni A,Fiaccadori F

更新日期：1988-08-01 00:00:00

abstract：:A technique is described for the isolation and culture of Kupffer cells (Kc) from needle and surgical liver biopsies of humans and rats. The isolation procedure is based on puncture perfusion of the specimen with collagenase and pronase, and subsequent gradient centrifugation. The ultrastructure of the cultured cells ...

journal_title：Journal of hepatology

authors： Van Bossuyt H,Wisse E

更新日期：1988-08-01 00:00:00

abstract：:The clinical relevance of a new antimitochondrial antibody, anti-M9, reacting with an outer membrane-associated antigen on liver mitochondria is described. Sera from 22 anti-M2-negative patients with histologically proven primary biliary cirrhosis (PBC) who had been followed for 5-15 years were tested for anti-M9 in t...

journal_title：Journal of hepatology

authors： Klein R,Klöppel G,Fischer R,Fintelmann V,Müting D,Berg PA

更新日期：1988-06-01 00:00:00

abstract：:Evidence is accumulating that there are changes in the expression of antigens on biliary epithelium in early primary biliary cirrhosis and graft rejection. If any of the biliary diseases including rejection are associated with specific alterations in biliary glycoprotein structure, lectin histochemistry could be usefu...

journal_title：Journal of hepatology

authors： Rhodes JM,Hubscher S,Black R,Elias E,Savage A

更新日期：1988-06-01 00:00:00

abstract：:A substantial production of prostaglandin E2 (PGE2) was induced in primary cultures of rat Kupffer cells by zymosan, calcium ionophore A23187, phorbol ester and arachidonic acid, whereas contact with latex particles, glucan or immunocomplexes led to a minor PGE2 release only. Superoxide generation, on the other hand, ...

journal_title：Journal of hepatology

authors： Dieter P,Schulze-Specking A,Decker K

更新日期：1988-04-01 00:00:00

abstract：:In order to document the incidence of hepatitis delta virus (HDV) replication markers and their relationship to HBV replication, 91 HBsAg chronic carriers were studied. Of these, 51 were anti-HD-positive (19 HBeAg-positive and 32 anti-HBe-positive). Liver HDAg was found in 75% of anti-HD-positive patients. Of the 19 p...

journal_title：Journal of hepatology

authors： Bas C,Bartolomé J,La Banda F,Porres JC,Quiroga JA,Mora I,Carreño V

更新日期：1988-04-01 00:00:00

abstract：:The efficacy of hematin has been evaluated in eight patients with acute intermittent porphyria: six with acute attacks and two with chronic subacute symptoms. Hematin suppressed the chemical signs of porphyria in all patients and the symptoms in those with acute attacks. The clinical response to hematin occurred unifo...

journal_title：Journal of hepatology

authors： Bissell DM

更新日期：1988-02-01 00:00:00

abstract：:We report a case of chronic active hepatitis caused by benzarone, a benzofuran derivative used in Europe for the treatment of peripheral venous disorders. Jaundice and serum alanine aminotransferase activity increased while drug administration was continued, but promptly decreased when it was eventually interrupted. L...

journal_title：Journal of hepatology

authors： Babany G,Larrey D,Pessayre D,Degott C,Rueff B,Benhamou JP

更新日期：1987-12-01 00:00:00

abstract：:In a rat model of chronic portal hypertension we studied ethanol-induced gastric mucosal damage and the effects of pretreatment by propranolol and sucralfate. Susceptibility to ethanol was increased in chronic portal hypertensive rats compared with sham-operated rats (55 +/- 8% vs. 25 +/- 4%). Both acute pretreatment ...

journal_title：Journal of hepatology

authors： Geoffroy P,Duchateau A,Thiéfin G,Zeitoun P

更新日期：1987-10-01 00:00:00

abstract：:A diagnostic test has been developed to detect hepatitis B virus (HBV) DNA in human sera. This test involves a dot-blot technique in which non-radioactive nucleic acid labelled with 2-acetylaminofluorene (AAF) is used as probe. Two series of human sera from 228 blood donors and 113 HBsAg chronic carriers were tested b...

journal_title：Journal of hepatology

authors： Larzul D,Thiers V,Courouce AM,Bréchot C,Guesdon JL

更新日期：1987-10-01 00:00:00